detriment

n.

1. Damage, harm, or loss: took a long leave of absence without detriment to her career. See synonyms at disadvantage.
2. Something that causes damage, harm, or loss: Smoking is now considered a detriment to good health.

[Middle English, from Old French, from Latin dētrīmentum, from dētrītus, past participle of dēterere, to lessen, wear down : dē-, de- + terere, to rub.]